Freeze & Thaw

March 14, 2023

Cold chain handling for fermentation: Single-use solutions to lower costs

Alexander Fuchs | Single Use Support
Alexander Fuchs

As expert for cold chain handling in bioprocessing, Single Use Support is providing solutions to meet challenges for safe storing and shipping associated with right freezing and thawing methods and temperature control for long-term storage. Their development approach leads to innovative systems that enable manufacturers to replace manual processes with fully automated end-to-end processes that not only push efficiency but also increase output.

March 8, 2023

Thawing drug substance: best practices

micheal-eder
Michael Eder

For drug substances that undergo a freezing process during manufacturing, thawing at some point is only a logical consequence. However, there are several factors to be considered for this seemingly easy procedure – find out more in this article!

March 7, 2023

Freezing drug substance – taking control over large volume pharmaceutical freezing

Alexander Fuchs | Single Use Support
Alexander Fuchs

Freezing large volumes of drug substance can be a challenging endeavor. In this article, we will discuss main considerations as well as possible solutions for this delicate process.

February 28, 2023

Shipping pharmaceutical liquids and its challenges

Claus Exenberger - Single Use Support
Claus Exenberger

The global distribution of pharmaceuticals is complex and demanding, requiring precise handling and storage of sensitive products. With the rise of personalized medicine and the increasing globalization of the industry, the need for safe and efficient shipping and supply chain has never been more important.

February 10, 2023

Why CDMOs are increasingly using single-use systems

michael-muehlegger
Michael Mühlegger

By combining a number of benefits, single-use technologies that are compliant with cGMP and GAMP seem the perfect choice. For manufacturers of drug substances, they provide a more efficient, cost-effective, and scalable solution than stainless-steel tanks by offering. 

February 10, 2023

CDMO in Biopharma: Opportunity or risk?

michael-muehlegger
Michael Mühlegger

Both, CDMOs and CMOs, are offering major opportunities in biopharma for startups and emerging companies as well as for established players who are approaching the limits of their manufacturing facilities or are generally looking to outsource parts of or their entire commercial production. 

January 3, 2023

Best choice for cold storage of Biopharmaceuticals - A Comparison

Alexander Fuchs | Single Use Support
Alexander Fuchs

What's the best choice for long-term cold storage of valuable drug substance? Comparing different Biopharma technologies.

December 19, 2022

Downstream processing with single-use systems

bernhard-schlichtner
Bernhard Schlichtner

One would think that a sector like the fast-paced biomanufacturing industry could not get any faster. Yet, increased speed-to-market and ever more efficient manufacturing continue to drive product and process development. This is why single-use technologies have become increasingly popular. Read more about single-use systems for downstream processing in this article. 

December 19, 2022

What is upstream and downstream processing?

bernhard-schlichtner
Bernhard Schlichtner

Upstream and downstream processing are two steps inherent to the production of active pharmaceutical ingredients (API) used in biopharmaceuticals. The production is challenged by increasing regulation and manufacturing costs. This calls for flexible solutions, which is why a growing number of manufacturing processes utilize single-use systems

November 8, 2022

Controlling cryogenic freezing with liquid nitrogen

daniel-tischler
Daniel Tischler

To control cryogenic freezing is not an easy task, especially when liquid nitrogen is involved. To keep small molecules chemically stable and prevent chemical degradation, the right practices have to be in place. Find out everything about controlled cryogenic freezing with LN2 in this article!

October 13, 2022

Controlled freezing of ADCs

johannes-kirchmaier
Johannes Kirchmair

Antibody-drug conjugates might revolutionize the treatment of cancer and various other diseases. However, there are some challenges to overcome in their handling, including controlled freezing – find out more in this article!

August 1, 2022

Cryogenic Freezing: All you need to know

daniel-tischler
Daniel Tischler

Cryopreservation is an effective procedure for the quality-preserving storage of many biomaterials. Find out what cryopreservation actually is, what has to be considered along the process and where it is applied – all summed up in this article.