Bioconjugates

Explore our comprehensive articles on bioconjugates, delving into the science and innovation behind this crucial biopharmaceutical technology. From the latest research trends to practical applications, we cover everything you need to know. Single Use Support offers cutting-edge solutions for the safe and efficient handling of bioconjugates to ensure product integrity.

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All articles about Bioconjugates

Bioconjugates

FDA approved Antibody Drug Conjugates (ADCs)

ADCs offer new, highly promising approaches in the therapy of various cancer types, and the number of approved ADCs is continuously growing. In this article, we will have a look at ADCs currently approved.

michael-muehlegger

Michael Mühlegger

May 7, 2024

Bioconjugates

ADC manufacturing: Process, Challenges & Solutions

Scale-up and industrial production of ADCs face complications due to the high safety measures which need to be taken to guarantee product efficacy and a protected working environment for staff and manufacturers. In this article we seek out to give you an overview of the different challenges during ADC manufacturing while also introducing solutions which help to ensure aseptic production methods through single-use-technologies and end-to-end systems. 

BRMO

Brian Moloney

May 5, 2024

Bioconjugates

Transport & Storage of Antibody Drug Conjugates (ADCs)

ADCs can be described as a new rising star among biopharmaceutics. They are able to specifically target and destroy cancer cells very effectively. Their levels of toxicity can vary depending on several factors, including their specific design and the potency of the cytotoxic drug. This is why safe handling in between facilities is such an important issue and must not be taken lightly.

BRMO

Brian Moloney

May 9, 2023

Bioconjugates

Bioconjugates: Examples & Applications

Bioconjugates are powerful tools in several areas of life sciences and beyond. In this article, we will have a look at the technology in general as well as at examples of bioconjugates in specific fields.

micheal-eder

Michael Eder

April 26, 2023

Bioconjugates

Examples of Antibody-drug conjugates

Depending on their constituents, ADCs are extremely variable and can be used for several, very distinct purposes. In this article, we will present you 5 examples of ADCs and their respective characteristics.

BRMO

Brian Moloney

April 25, 2023

Bioconjugates

ADC technology simply explained

ADC technology has revolutionized several fields in medicine and research. In this article, we will shed light on this groundbreaking technology.

daniel-tischler

Daniel Tischler

April 25, 2023

Bioconjugates

7 Must-Known Facts About Antibody-Drug Conjugates (ADCs)

Antibody drug conjugates (ADCs) are a rapidly growing field of interest in biopharmaceutics. In comparison to conventional chemotherapy treatments, ADCs have the potential to destroy cancerous cells without damaging healthy cells in the process. In this article we will give you an introduction to this important and rapidly growing field. 

BRMO

Brian Moloney

April 24, 2023

Bioconjugates

Safe Filling & Aliquoting of Antibody Drug Conjugates (ADCs)

The safe handling of ADCs or other HPAPIs is a complex and elaborate process that requires specialized facilities and a safe, sterile environment. The filling/aliquoting step in particular calls for great care and specific equipment to ensure sterility and rule out any potential cross-contamination as well as potential harm to handling staff.

BRMO

Brian Moloney

April 24, 2023

Bioconjugates

Bioconjugates manufacturing & the advances with single-use technology

The manufacturing of bioconjugates is a complex process that involves linking a drug payload with a targeting moiety using a linker. The process is highly specific and requires careful optimization to ensure that the bioconjugate is effective and safe for use in patients. Single-use technology has revolutionized the manufacturing of bioconjugates by offering a range of benefits over traditional stainless-steel manufacturing. Therefore, this article will pay special attention to this subject. 

BRMO

Brian Moloney

April 24, 2023

Bioconjugates

Bioconjugation simply explained

Bioconjugation is a pharmaceutical technique that is gaining more and more importance, most of all in cancer therapy. In this article, we will provide some basic information on bioconjugation, but also discuss major challenges related to this field.
 

michael-muehlegger

Michael Mühlegger

April 20, 2023

Bioconjugates

History & Development of ADCs

Since the first ADCs entered clinical trials in the 1990s, they have shown great promise in treating a variety of cancers and other diseases. However, the development of ADCs has also been marked by challenges and setbacks, including issues with efficacy, safety, and manufacturing. In this article, we will explore the history of ADCs, from their early development to the latest advances in technology and applications.

micheal-eder

Michael Eder

April 14, 2023

Bioconjugates

ADC companies: Big players working with antibody drug conjugates

The antibody-drug conjugates (ADCs) market is expected to grow significantly in the next few years. But what are the key players in this competitive landscape? Find out more in this article!

micheal-eder

Michael Eder

November 7, 2022

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eBook: Filling Gaps in Managing Large Volumes of Biologics

Aseptic aliquotation and cryopreservation of drug substances are crucial process steps in bioprocessing. Even though they’re not in the spotlight of biomanufacturing. In drug development and drug delivery, biologics must be transferred at numerous occasions. Along the journey of monoclonal antibodies, vaccines and more, the drug substance passes lots of process steps where liquid transfer is required. This is relevant for the transitions between upstream processing, downstream processing and fill & finish, but also within these manufacturing milestones. The market of fluid & cold chain management has great growth potential and is on its way to professionalization and industrialization. To meet the challenges of manufacturing drug substances, Single Use Support helps manufacturers and CDMOs to advance their fluid & cold chain management process to achieve a secure and efficient process for liquids on the basis of single-use bags.

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Whitepaper: How Controlled & Scalable Freezing Becomes Reality

Scalability around freezing means the ability to guarantee constant freezing kinetics on proteins (biopharmaceutical molecules) in all scales, filling volumes and loading scenarios. This guide covers how to achieve scalable freezing & thawing of biopharmaceuticals by showing What is scalability? Setup for controlled icefront growth speed Scalability results Outcomes

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Case Study RoSS.pFTU: The ROI of Bulk Freezing with Plate Freezers

An CDMO aspires to achieve improved freezing control, uniformity, and scalability when freezing BDS. New technologies are meant to reduce the need for manual handling as well as increase process efficiency and throughput. The goal was to evaluate and determine the return on investment (ROI) of cryovessels and plate freezers when freezing bulk.