End-to-end solution

March 29, 2023

Biopharma supply chain – 7 risks to be aware of

michael-muehlegger
Michael Mühlegger

The entire biopharma industry depends on intact supply chain in order to provide patients with the drug products they need. However, there are several factors that can put the integrity of supply chain at risk. In this article, we will discuss seven of them and explore what can be done to circumvent them.

March 22, 2023

Bulk drug substance management

micheal-eder
Michael Eder

The following article aims to take a closer look at the term “bulk drug substance” and its meaning, as well as to investigate smart solutions to shorten the phase between development and blockbuster production. Read more about the solution for the biopharmaceutical industry!

March 17, 2023

Microbial Fermentation Manufacturing: Advances through single-use technologies

daniel-tischler
Daniel Tischler

Microbial fermentation is a powerful, flexible microbiology process used to generate microbial cells or biomass such as proteins and enzymes for the production of vaccines and therapeutics. There are still some challenges to overcome. Many of these challenges in fermentation manufacturing can be solved by replacing traditional systems with single-use technologies. 

March 16, 2023

Filling & Freezing large volumes for fermentation in less than 8 hours

daniel-tischler
Daniel Tischler

The filling and freezing of large volumes for fermentation is an essential part during different production steps in upstream and downstream processing.  In the following, we will explain why it is important to act fast and how an optimization of the process can be achieved. 

March 14, 2023

Cold chain handling for fermentation: Single-use solutions to lower costs

mike-marciniak
Mike Marciniak

As expert for cold chain handling in bioprocessing, Single Use Support is providing solutions to meet challenges for safe storing and shipping associated with right freezing and thawing methods and temperature control for long-term storage. Their development approach leads to innovative systems that enable manufacturers to replace manual processes with fully automated end-to-end processes that not only push efficiency but also increase output.

March 13, 2023

Safe handling of bulk drug substances

daniel-tischler
Daniel Tischler

When dealing with bulk drug substances, there are several risks to consider along the processing steps. Read more on the critical steps in bulk drug substance production and possible solutions – in this article.

March 1, 2023

Meeting cGMP regulations with innovative single-use technologies

michael-muehlegger
Michael Mühlegger

Manufacturers in the pharmaceutical industry are required to comply with cGMP (Current Good Manufacturing Practice). End-to-end solutions based on automated single-use technologies are an auspicious choice for drug substance manufacturers, given their many advantages. Their implementation in the manufacturing process promises efficiency, high product quality, cost reduction, and energy savings.

March 1, 2023

cGMP - everything you need to know

michael-muehlegger
Michael Mühlegger

The current Good Manufacturing Practice (cGMP) regulations - originated and checked by the FDA - apply to companies operating in pharmaceutical, biotech, or med tech industries. They require the latest standards in terms of production, manufacturing, and packaging and thereby ensure pharmaceutical quality meaning quality in manufacturing processes and patient safety as the ultimate goal. The detailed requirements, importance of cGMP, and how companies can best meet the cGMP regulations, are discussed in the following.

February 28, 2023

Reducing product loss & human error in pharmaceutical fermentation

daniel-tischler
Daniel Tischler

Pharmaceutical manufacturing processes, including pharmaceutical fermentation, are still prone to human error and product loss. The challenges can be overcome by moving to automated processes that eliminate the need for slow and error-prone manual handling. Adopting automated end-to-end solutions based on single-use technologies minimizes, if not eliminates, human error and product loss.

February 10, 2023

Why CDMOs are increasingly using single-use systems

michael-muehlegger
Michael Mühlegger

By combining a number of benefits, single-use technologies that are compliant with cGMP and GAMP seem the perfect choice. For manufacturers of drug substances, they provide a more efficient, cost-effective, and scalable solution than stainless-steel tanks by offering. 

February 10, 2023

How to choose a CDMO? 7 Considerations to be made

michael-muehlegger
Michael Mühlegger

Choosing the right CDMO or CMO to work with is an important decision. Irrespective of which stage biopharma and pharma companies find themselves in, there are certain things to consider that are valid for any stage throughout your production process.

February 10, 2023

CDMO in Biopharma: Opportunity or risk?

michael-muehlegger
Michael Mühlegger

Both, CDMOs and CMOs, are offering major opportunities in biopharma for startups and emerging companies as well as for established players who are approaching the limits of their manufacturing facilities or are generally looking to outsource parts of or their entire commercial production.