Discover everything you need to know about freeze & thaw processes in our detailed articles. These include the freezing process to sub-zero temperatures, the cold storage and cold shipping of biopharmaceuticals. Learn about different methods, best practices, and advanced cryopreservation techniques to ensure the highest quality and stability of your biopharmaceutical products. Explore how our innovative freezing solutions are applied across various areas, including cell banking, monoclonal antibody preservation, and bioconjugate stability.
Freeze & Thaw
Temperature plays a significant role in the production and distribution of several revolutionary biologics. But how does the pharmaceutical cold chain work, and what temperature ranges are most frequently chosen? You will find out in this article!
Alexander Fuchs
July 25, 2022
Freeze & Thaw
Plate freezing is a process where a product’s temperature is reduced by the means of contact with cold surfaces. Thus, a defining step in the freeze-thaw process for conservation, with several advantages for biopharma.
Alexander Fuchs
May 18, 2022
Freeze & Thaw
The collaboration between Single Use Support and the National Institute for Bioprocessing Research and Training (NIBRT) exemplifies a shared commitment to advancing scientific knowledge and driving innovation in the bioprocessing industry.
Michael Eder
August 13, 2024
Freeze & Thaw
Freezing small volumes extends beyond laboratory settings to include commercialized manufacturing processes for small batches in biomanufacturing, like cell banking, gene therapies utilizing viral vectors, lipid nanoparticles, and fill & finish procedures.
Alexander Fuchs
November 20, 2023
Freeze & Thaw
In the biopharmaceutical sector, the utilization of F-Gases is on a decline. However, the need for cryopreservation of drug substances will remain. In order to contribute to a more environmentally friendly freezing of drugs, more sustainable technologies need to be developed and applied. But is sustainable freezing even possible?
Alexander Fuchs
September 6, 2023
Freeze & Thaw
It is many decades since cryovessels emerged as a groundbreaking solution in the biopharmaceutical industry, enabling the safe and efficient storage of bulk drug substances. However, the introduction of plate-based freezing methods has further advanced the technology available for the freezing of biopharmaceuticals, offering improved product quality and consistency.
Daniel Tischler
July 28, 2023
Freeze & Thaw
Not all biopharmaceuticals are suitable for freeze-drying. Depending on the specific stability requirements the preservation of biopharmaceuticals is either with cryopreservation or lyophilization.
Michael Eder
July 28, 2023
Freeze & Thaw
Considering the manifold applications of mRNA, it is essential to establish optimal freezing processes that maintain viability and effectiveness. In this article, we will compare different freezing methods for mRNA.
Alexander Fuchs
July 4, 2023
Freeze & Thaw
New technologies, sauch as plate-based freezing and thawing based on single-use systems, improve process efficiency and product quality. Innovative solutions are breaking the ice for the evolution of bulk drug freezing.
Michael Eder
June 23, 2023
Freeze & Thaw
Spray drying often leads to product losses of mAbs or vaccines of more than 30%. Plate-based freezing and thawing solutions enable controlled handling of bulk intermediates safely in a vendor-independent, modular and scalable fluid and cold chain management process.
Daniel Tischler
April 12, 2023
Freeze & Thaw
The global distribution of pharmaceuticals is complex and demanding, requiring precise handling and storage of sensitive products. With the rise of personalized medicine and the increasing globalization of the industry, the need for safe and efficient shipping and supply chain has never been more important.
Claus Exenberger
February 28, 2023
Freeze & Thaw
What's the best choice for long-term cold storage of valuable drug substance? Comparing different Biopharma technologies.
Alexander Fuchs
January 3, 2023
Freeze & Thaw
Freezing and Thawing drug substances in both primary packagings, single-use bags and bottles, in one platform is possible with hybrid freezers. Biopharmaceutical manufacturers and CMOs face challenges to prevent the effect of cryoconcentration during freezing, leading to loss of product quality. Tests have shown that hybrid freezer defy cryoconcentration with homogeneous freezing of both single-use bags and bottles.
Daniel Tischler
December 7, 2022
Freeze & Thaw
To control cryogenic freezing is not an easy task, especially when liquid nitrogen is involved. To keep small molecules chemically stable and prevent chemical degradation, the right practices have to be in place. Find out everything about controlled cryogenic freezing with LN2 in this article!
Daniel Tischler
November 8, 2022
Articles by Biopharmaceutical Products:
Articles by Manufacturing Processes:
E-Book
In this publication we show that the initial price can be deceiving and there are significant additional costs during ongoing usage in the long term. Plate freezers ensure a complete, consistent, and fast freezing (and thawing) to ensure the quality of your high-valued drug substance is maintained, and through simple lifecycle analysis they outpace conventional options regarding total costs.
E-Book
Scalability around freezing means the ability to guarantee constant freezing kinetics on proteins (biopharmaceutical molecules) in all scales, filling volumes and loading scenarios. This guide covers how to achieve scalable freezing & thawing of biopharmaceuticals by showing What is scalability? Setup for controlled icefront growth speed Scalability results Outcomes
E-Book
The study was conducted aiming to optimize the cryogenic freezing process of the mammalian CHO-K1 cell line with an innovative controlled rate liquid nitrogen freezer (RoSS.LN2F). The study incorporated three viability assays to comprehensively assess the impact of varying freezing rates on post-thaw cell recovery | Trypan blue | LIVE/DEAD | Fluorescence.
