Nucleic Acids

Explore the fascinating world of mRNA, pDNA, oligonucleotides, and more nucleic acids through our insightful articles. Learn about their roles in modern medicine and cutting-edge research. Single Use Support provides innovative solutions for the transport and storage of mRNA and plasmids, ensuring their stability and effectiveness.

Featured Articles

Fill Filtration for Oligonucleotide Purifcation

Nucleic Acids

Oligonucleotide manufacturing – challenges & solutions

Oligonucleotide manufacturing. Optimizing fluid management, freezing & cold storage | Purification Oligonucleotides

Michael Mühlegger

October 25, 2024

Nucleic Acids

mRNA technology simply explained

New advances in mRNA technology are happening regularly and rapidly. The prevention and treatment of viruses and immunogenic diseases has become possible through new therapeutics that use messenger RNA to help the body produce specific proteins. Nevertheless, the heightened demand for mRNA drugs leads to challenges for its production.

Daniel Tischler

June 15, 2023

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All articles about Nucleic Acids

Nucleic Acids

Oligonucleotide manufacturing – challenges & solutions

Oligonucleotide manufacturing. Optimizing fluid management, freezing & cold storage | Purification Oligonucleotides

Michael Mühlegger

October 25, 2024

Nucleic Acids

Oligonucleotides simply explained

What are oligonucleotides? Nucleic acid types | RNA oligonucleotides | DNA oligos | Types of Oligonucleotides

Michael Mühlegger

October 25, 2024

RNase Contamination Challenges - Single Use Support

Nucleic Acids

RNase Contamination – Challenges & Solutions

This article explores the challenges posed by RNase contamination and the solutions that can be employed to mitigate these risks. RNase contamination | Ribonuclease inhibitors | RNase-free equipment

David Seifert

August 13, 2024

Single Use Support RNase Contamination RNA

Nucleic Acids

RNase: Ribonuclease Simply Explained

RNase contamination can lead to the degradation of RNA, thereby compromising the efficacy of RNA-based drugs. Types of RNase | RNase and DNase | Role of DEPC

David Seifert

August 12, 2024

Nucleic Acids

Single-use technology in mRNA manufacturing

MRNA manufacturing demands for highest accuracy, safety, and compliance. In this article, we will find out how single-use technologies can be used to achieve improvements for mRNA production and processing.

Brian Moloney

January 8, 2024

Nucleic Acids

Optimizing pDNA production using advanced single-use technologies

Considering the widespread need for efficient pDNA production, the industry is seeking to improve the current manufacturing process. In this article, we will discover how single-use technologies can contribute to pDNA manufacturing optimizations.

Khalil Essani

November 10, 2023

Nucleic Acids

Plasmid DNA manufacturing companies – market overview

In this article, we will give an overview of the pDNA manufacturing market – not only taking a look at the dry figures, but also highlighting the services that are offered by important plasmid DNA manufacturing companies.

Daniel Tischler

September 13, 2023

Nucleic Acids

What is the function of plasmid DNA?

Plasmid DNA fulfills several functions in bacteria, but they are also widely used in the biopharma sector. In this article, we will uncover their key functions.

Michael Mühlegger

September 13, 2023

Nucleic Acids

Plasmid DNA manufacturing: The process simply explained

The pDNA manufacturing process is multifaceted yet essential in the biopharmaceutical industry. Here, we will describe the process step by step.

Michael Mühlegger

September 12, 2023

Nucleic Acids

What is a plasmid?

Plasmids are part of the genetic material in bacteria, complementing chromosomal DNA with additional functions. But there is much more to plasmids, as you can read in this article.

Michael Mühlegger

September 7, 2023

Nucleic Acids

Plasmid DNA – 7 facts about pDNA

Plasmid DNA is not only found in bacteria, but also ubiquitous in biotechnology. In this article, we have collected 7 interesting facts on pDNA.

Michael Mühlegger

September 7, 2023

Nucleic Acids

What is mRNA?

mRNA is the acronym for messenger ribonucleic acid – but there is much more to know about this fascinating molecule, as it is essential in elementary biological processes. In this article, we will give readers a brief explanation of what mRNA actually is and discuss its application in medicine as well as recent advances in mRNA technology.

Michael Eder

July 6, 2023

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Recommended Downloads

E-Book

eBook: Filling Gaps in Managing Large Volumes of Biologics

Aseptic aliquotation and cryopreservation of drug substances are crucial process steps in bioprocessing. Even though they’re not in the spotlight of biomanufacturing. In drug development and drug delivery, biologics must be transferred at numerous occasions. Along the journey of monoclonal antibodies, vaccines and more, the drug substance passes lots of process steps where liquid transfer is required. This is relevant for the transitions between upstream processing, downstream processing and fill & finish, but also within these manufacturing milestones. The market of fluid & cold chain management has great growth potential and is on its way to professionalization and industrialization. To meet the challenges of manufacturing drug substances, Single Use Support helps manufacturers and CDMOs to advance their fluid & cold chain management process to achieve a secure and efficient process for liquids on the basis of single-use bags.

Single-Use-Support-Controlled-Freezing-Biopharmaceuticals

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Whitepaper: How Controlled & Scalable Freezing Becomes Reality

Scalability around freezing means the ability to guarantee constant freezing kinetics on proteins (biopharmaceutical molecules) in all scales, filling volumes and loading scenarios. This guide covers how to achieve scalable freezing & thawing of biopharmaceuticals by showing What is scalability? Setup for controlled icefront growth speed Scalability results Outcomes

E-Book

App Note: The Chilled Future of RNA Therapeutics Filling & Freezing Applications

Traditional and rigid manufacturing processes are not for Advanced Therapies. Since novel therapies push limits in biotechnology, life science needs to keep up with adequate process solutions around commercialization of these specific therapies. Yes, SARS-CoV-2 has largely boosted the acceptance of mRNA in vaccines. And RNA vaccines and therapeutics won’t stop to fulfil unmet medical needs. But biotechs and biopharma companies continuously advancing novel treatments while solution provider drive process optimization to increase efficiency. With different product characteristics come different challenges and risks for fluid management. Therefore, modular, and flexible technologies facilitate ATMPs (Advanced Therapy Medicinal Products) manufacturing. Adjustability of process solutions to different requirements and scenarios will satisfy the needs of biomanufacturing and biotechnology companies as well as CMOs and CDMOs along the journey from drug development to commercialization.