All articles about Manufacturing Processes
Manufacturing Processes
Cryogenic Freezing: All you need to know
Cryopreservation is an effective procedure for the quality-preserving storage of many biomaterials. Find out what cryopreservation actually is, what has to be considered along the process and where it is applied – all summed up in this article.
Daniel Tischler
August 1, 2022
Manufacturing Processes
Case Study: Reducing product loss | Hybrid for primary packaging
Harmonize the process for different types of single-use primary packaging. Protective shell solutions and hybrid systems optimize liquid transfer in Biopharma.
Claus Exenberger
July 28, 2022
Manufacturing Processes
Pharmaceutical cold storage – overview of all freezing ranges
Temperature plays a significant role in the production and distribution of several revolutionary biologics. But how does the pharmaceutical cold chain work, and what temperature ranges are most frequently chosen? You will find out in this article!
Alexander Fuchs
July 25, 2022
Manufacturing Processes
Ultra-cold freezing and storing – considerations & solutions
Implementing cold freezing and storing in supply chains is oftentimes inevitable when dealing with certain biopharmaceuticals. Learn what the main considerations are and find out how to face related challenges.
Daniel Tischler
July 19, 2022
Manufacturing Processes
Case Study: Reducing product loss | Bag-independence
Learn about the benefits of supplier-agnostic solutions around single-use bioprocess containers that help minimize product loss.
Claus Exenberger
June 20, 2022
Manufacturing Processes
Case Study: Reducing product loss | Cost-efficiency
It is the key issue in the management of bulk medicines: How can product loss be avoided or at least reduced? This article explains everything about this topic!
Claus Exenberger
June 8, 2022
Manufacturing Processes
Plate freezing: best approach for freezing biopharmaceuticals
Plate freezing is a process where a product’s temperature is reduced by the means of contact with cold surfaces. Thus, a defining step in the freeze-thaw process for conservation, with several advantages for biopharma.
Alexander Fuchs
May 18, 2022
Manufacturing Processes
Industry 4.0 in Biomanufacturing: RoSS.KSET as an example
Industry 4.0 has long become reality in many branches. In Pharma 4.0 intelligent industrial applications and IoT enable players in the bioeconomy industry to transition to operations that help them improve their productivity. Pharma 4.0 also has become a major part in single-use technologies, as it brings companies to the next level concerning the scalability, productivity and efficiency of their processes and products.
Michael Mühlegger
May 18, 2022
Manufacturing Processes
Extractables and leachables: definitions, differences & facts
Extractables and leachables are contaminants that are causing biopharmaceutical manufacturers headaches, as they can lead to impurities of highly valuable drug products. While extractables and leachables both describe foreign matter that can lead to contamination of highly valuable drug products, it is important to understand their characterization but also the difference between the two.
David Seifert
April 12, 2022
Manufacturing Processes
Storage Density in Biopharma Manufacturing Facilities
Single-use bags with its flat shape is predestined for stacking and offer great solutions to increase storage density on-site but also for shipment. The combination of both, single use bag and RoSS® shells (Robust Storage and Shipping) makes them a cost-effective solution, as they require little storage space. RoSS® shells are available for all sizes and suppliers of single-use bags.
Michael Eder
March 24, 2022
Manufacturing Processes
How Pharma 4.0 eliminates human errors in pharmaceutical industry
Pharma 4.0 aims at improving risk management. It aims at updating the pharmaceutical industry and ensuring data integrity by incorporating advanced digital formats and enablers into the current Pharmaceutical Quality System (ICH Q10). The final goal is to minimize, if not eradicate, human error.
Michael Mühlegger
March 23, 2022
Manufacturing Processes
Scalability of single-use drug substance production
The aim was to achieve a freezing process where the last point of freeze always happens at the same time throughout all scales. If successful, the generated freezing curves will look very similar. Temperature ramps have been used to slow down or accelerate the freezing process.
Michael Eder
March 21, 2022
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