All articles about Manufacturing Processes
Manufacturing Processes
What is upstream and downstream processing?
Upstream and downstream processing are two steps inherent to the production of active pharmaceutical ingredients (API) used in biopharmaceuticals. The production is challenged by increasing regulation and manufacturing costs. This calls for flexible solutions, which is why a growing number of manufacturing processes utilize single-use systems
Daniel Tischler
December 19, 2022
Manufacturing Processes
How Hybrid Freeze-Thaw Platforms Defy Cryoconcentration
Freezing and Thawing drug substances in both primary packagings, single-use bags and bottles, in one platform is possible with hybrid freezers. Biopharmaceutical manufacturers and CMOs face challenges to prevent the effect of cryoconcentration during freezing, leading to loss of product quality. Tests have shown that hybrid freezer defy cryoconcentration with homogeneous freezing of both single-use bags and bottles.
Daniel Tischler
December 7, 2022
Manufacturing Processes
Controlling cryogenic freezing with liquid nitrogen
To control cryogenic freezing is not an easy task, especially when liquid nitrogen is involved. To keep small molecules chemically stable and prevent chemical degradation, the right practices have to be in place. Find out everything about controlled cryogenic freezing with LN2 in this article!
Daniel Tischler
November 8, 2022
Manufacturing Processes
Single-use bioprocessing: Why it pays off to switch to single-use systems now
Single-use systems are looking ahead a bright future – but what is it that manufacturers need to consider before the switch? Learn more about it in this article!
David Seifert
September 15, 2022
Manufacturing Processes
Case Study - Reducing Product Loss | Process-independence
Optimize process operations and save both, CAPEX and OPEX, when you plan to expand product capacities for biopharmaceutical manufacturing - especially for greenfield facilities. Read how you gain process-independence which in turn increases (cost-)efficiency in manufacturing processes.
Claus Exenberger
August 22, 2022
Manufacturing Processes
Simplifying Cryopreservation of Cell Monolayers
Advanced cell-based assay workflow with CryoLogyx Thaw and Test pre-plated cell and controlled, scalable freezing process solution RoSS.pFTU to achieve effective cryopreservation of cells.
Brian Moloney
August 9, 2022
Manufacturing Processes
Cryogenic Freezing: All you need to know
Cryopreservation is an effective procedure for the quality-preserving storage of many biomaterials. Find out what cryopreservation actually is, what has to be considered along the process and where it is applied – all summed up in this article.
Daniel Tischler
August 1, 2022
Manufacturing Processes
Case Study: Reducing product loss | Hybrid for primary packaging
Harmonize the process for different types of single-use primary packaging. Protective shell solutions and hybrid systems optimize liquid transfer in Biopharma.
Claus Exenberger
July 28, 2022
Manufacturing Processes
Pharmaceutical cold storage – overview of all freezing ranges
Temperature plays a significant role in the production and distribution of several revolutionary biologics. But how does the pharmaceutical cold chain work, and what temperature ranges are most frequently chosen? You will find out in this article!
Alexander Fuchs
July 25, 2022
Manufacturing Processes
Ultra-cold freezing and storing – considerations & solutions
Implementing cold freezing and storing in supply chains is oftentimes inevitable when dealing with certain biopharmaceuticals. Learn what the main considerations are and find out how to face related challenges.
Daniel Tischler
July 19, 2022
Manufacturing Processes
Case Study: Reducing product loss | Bag-independence
Learn about the benefits of supplier-agnostic solutions around single-use bioprocess containers that help minimize product loss.
Claus Exenberger
June 20, 2022
Manufacturing Processes
Case Study: Reducing product loss | Cost-efficiency
It is the key issue in the management of bulk medicines: How can product loss be avoided or at least reduced? This article explains everything about this topic!
Claus Exenberger
June 8, 2022
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