All articles about Manufacturing Processes
Manufacturing Processes
CDMO in Biopharma: Opportunity or risk?
Both, CDMOs and CMOs, are offering major opportunities in biopharma for startups and emerging companies as well as for established players who are approaching the limits of their manufacturing facilities or are generally looking to outsource parts of or their entire commercial production.
Michael Mühlegger
February 10, 2023
Manufacturing Processes
Best choice for cold storage of Biopharmaceuticals - A Comparison
What's the best choice for long-term cold storage of valuable drug substance? Comparing different Biopharma technologies.
Alexander Fuchs
January 3, 2023
Manufacturing Processes
Single-Use Technologies: Scalable, Modular Systems Bring Cost Efficiency to Bioprocessing
Ebook published at GEN News (Genetic Engineering & Biotechnology News): The evolution of single-use technologies (SUTs) is among the most important developments of biomanufacturing. There has been a shift toward SUT, which has enhanced manufacturing agility and flexibility greatly.
Michael Eder
December 22, 2022
Manufacturing Processes
Upstream processing with single-use systems
The manufacturing process of biopharmaceuticals such as monoclonal antibodies, mRNA and bioconjugates is divided into upstream and downstream processing. Manufacturers seeking reliable automation and optimization fit for scale-up are increasingly employing single-use bioreactors, titers, filtration and other components, especially during upstream.
Daniel Tischler
December 20, 2022
Manufacturing Processes
Downstream processing with single-use systems
One would think that a sector like the fast-paced biomanufacturing industry could not get any faster. Yet, increased speed-to-market and ever more efficient manufacturing continue to drive product and process development. This is why single-use technologies have become increasingly popular. Read more about single-use systems for downstream processing in this article.
Daniel Tischler
December 19, 2022
Manufacturing Processes
What is upstream and downstream processing?
Upstream and downstream processing are two steps inherent to the production of active pharmaceutical ingredients (API) used in biopharmaceuticals. The production is challenged by increasing regulation and manufacturing costs. This calls for flexible solutions, which is why a growing number of manufacturing processes utilize single-use systems
Daniel Tischler
December 19, 2022
Manufacturing Processes
How Hybrid Freeze-Thaw Platforms Defy Cryoconcentration
Freezing and Thawing drug substances in both primary packagings, single-use bags and bottles, in one platform is possible with hybrid freezers. Biopharmaceutical manufacturers and CMOs face challenges to prevent the effect of cryoconcentration during freezing, leading to loss of product quality. Tests have shown that hybrid freezer defy cryoconcentration with homogeneous freezing of both single-use bags and bottles.
Daniel Tischler
December 7, 2022
Manufacturing Processes
Controlling cryogenic freezing with liquid nitrogen
To control cryogenic freezing is not an easy task, especially when liquid nitrogen is involved. To keep small molecules chemically stable and prevent chemical degradation, the right practices have to be in place. Find out everything about controlled cryogenic freezing with LN2 in this article!
Daniel Tischler
November 8, 2022
Manufacturing Processes
Mission completed – and now? How RoSS® Shell is to be recycled
Once they have fulfilled their purpose to protect valuable biologics, the question for our RoSS containers arises: What now? This is why we summarized information on the recycling of our containers for single use bags in this article.
Claus Exenberger
October 12, 2022
Manufacturing Processes
Single-use bioprocessing: Why it pays off to switch to single-use systems now
Single-use systems are looking ahead a bright future – but what is it that manufacturers need to consider before the switch? Learn more about it in this article!
David Seifert
September 15, 2022
Manufacturing Processes
Case Study - Reducing Product Loss | Process-independence
Optimize process operations and save both, CAPEX and OPEX, when you plan to expand product capacities for biopharmaceutical manufacturing - especially for greenfield facilities. Read how you gain process-independence which in turn increases (cost-)efficiency in manufacturing processes.
Claus Exenberger
August 22, 2022
Manufacturing Processes
Simplifying Cryopreservation of Cell Monolayers
Advanced cell-based assay workflow with CryoLogyx Thaw and Test pre-plated cell and controlled, scalable freezing process solution RoSS.pFTU to achieve effective cryopreservation of cells.
Brian Moloney
August 9, 2022
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