Cell & Gene Therapy

Stay updated with the latest breakthroughs in cell and gene therapy through our expert-written articles. Discover how these therapies are revolutionizing modern medicine. Single Use Support provides robust solutions for the secure transport and storage of cell and gene therapy products, ensuring they maintain their efficacy.

Featured Articles

RoSS.FILL CGT Small Volumne_Product Photo-3-min

Cell & Gene Therapy

Revolutionizing Commercial Aliquotation in Advanced Therapies

Single Use Support unveils its latest customized innovation within the product range of automated of biopharmaceutical manufacturing, RoSS.FILL. With its unmatched precision and cutting-edge technology, RoSS.FILL CGT is a game-changer for the cell and gene therapy industry.

Brian Moloney

August 22, 2023

Automated filling and draining system for CGT - RoSS.FILL CGT

Cell & Gene Therapy

Single Use Support providing solutions for gene therapies

Biopharma solution provider Single Use Support announces an order from Genezen, a cell and gene therapy Contract Development and Manufacturing Organization (CDMO).

Michael Eder

September 8, 2021

Newsletter subscription

Get the latest delivered directly to your inbox!

Get the latest delivered directly to your inbox! You can unsubscribe at any time, no hard feelings. Privacy policy.

All articles about Cell & Gene Therapy

Cell & Gene Therapy

DMSO: Freezing Cells

Freezing cells is a process that requires more than simply placing them in a freezer with dimethyl sulfoxide (DMSO). It is a precise and meticulous process, where precision and expertise are essential. The goal is to achieve high cell viability and therefore high yield for cell-based therapies or cell banking.

Khalil Essani

October 11, 2024

Cell & Gene Therapy

Cell cryopreservation preparation process

This guide provides an overview of the necessary steps and considerations for preparing cells for cryopreservation. Key topics include selecting appropriate cells, cultivating and harvesting them under controlled conditions, utilizing proper cryoprotective agents, and applying specific freezing techniques.

Brian Moloney

September 3, 2024

Cell & Gene Therapy

The Role of Single-Use Systems in Cell and Gene Therapies

Ensuring that cell and gene therapy products are shipped at cold temperatures with robust controls is even more important for cell & gene therapies than it is for more traditional biopharmaceutical products.

Michael Mühlegger

July 8, 2024

Freezing Mammalian Cell Line for increased CHO cell viability

Cell & Gene Therapy

Study: Optimizing Cell Viability During CHO Cell Freezing

In a recent study, freezing protocols were tested with the RoSS.LN2F controlled liquid nitrogen freezer to find the optimal freezing rate for CHO-K1 cells in order to achieve maximum cell viability.

Alexander Fuchs

February 16, 2024

RoSS.KSET freezing single-use bags Cell Banking

Cell & Gene Therapy

Stressing Cells: The Role of Cryoprotectants in ATMP Cryopreservation

The objective of an optimal cryopreservation strategy is to deactivate (put on hold) degenerative cellular pathways and preserve proliferative potential by reducing the temperature below –130°C. To reduce the effects of ice crystal and osmotic injuries, cryopreservation protocols usually incorporate cryoprotective agents (CPAs).

Khalil Essani

February 8, 2024

Meeting cGMP standards for vaccine manufacturing

Cell & Gene Therapy

Regulations for Cryoprotectants in ATMP Cryopreservation

Adequate quality control samples retained before cell therapy treatment are a crucial component of effective regulation and need to represent the conditions and history in the cryobag. A deep dive into GMP Annex 1 on ATMP Cryopreservation.

Khalil Essani

February 7, 2024

RoSS.FILL CGT Lab Scale_product photo (7 von 10)-min

Cell & Gene Therapy

Increasing Patient Safety: Risk assessment for small volume fluid management

Autologous therapies and other ATMPs with small volumes exhibit certain specific requirements. The scope of handling advanced therapies require special handling and care. When handling of small volumes is already automated in an early stage, it is a way more straightforward path to commercialization of the drug product. The benefit of a closed systems with automated solutions add value by offering a higher degree of sterility, safety, and process flexibility.

Brian Moloney

December 4, 2023

Cell & Gene Therapy

Revolutionizing Commercial Aliquotation in Advanced Therapies

Brian Moloney

August 22, 2023

Cell & Gene Therapy

Cryopreservation techniques & best practice freezing methods

The preservation of cells at cryogenic temperature can be achieved using different techniques. This is far from a simple freezing process; it's a carefully controlled method that prevents the formation of ice crystals, thus maintaining the integrity of the biological material.

Brian Moloney

August 11, 2023

Cell & Gene Therapy

Cell viability & viability assays: 7 facts to be aware of

In research, medicine and biotechnology, cell viability is an elementary parameter and Critical Quality Attribute (CQA). In this article, we will present you 7 facts regarding the term, related concepts, improvement possibilities and more.

Brian Moloney

August 10, 2023

Cell & Gene Therapy

Cryopreservation: Purpose, process & applications

Cryopreservation is essential to maintain ex vivo viability of organic materials – indispensable, for instance, in fields like cell banking. In this article, we will explore central aspects of this technique.

Brian Moloney

August 10, 2023

Cell & Gene Therapy

How to measure and improve cell viability?

Cell viability is a fundamental parameter in cell-based biopharma processing and cell banking. Therefore, it is essential not only to measure cell viability, but also to take measures for its improvement. Learn more in this article.

Michael Eder

July 31, 2023

Discover more topics

Articles by Biopharmaceutical Products:

Articles by Manufacturing Processes:

Recommended Downloads

E-Book

eBook: Advancing ATMP Fluid Management

Simplifying complex process logistics in fluid and cold chain management for cell & gene therapies in small volumes

RoSS.pFTU Lab Scale - in process (4 von 9)

E-Book

App Note: "Bestcellers": Controlled Filling & Freezing of Cells

"Bestcellers": Controlled Filling & Freezing of Cells Advanced Fluid Management for Cell Culture, Freezing, Cell Banking and Cell Therapy

E-Book

Study: Increased CHO Cell Viability with Controlled Liquid Nitrogen Freezer

The study was conducted aiming to optimize the cryogenic freezing process of the mammalian CHO-K1 cell line with an innovative controlled rate liquid nitrogen freezer (RoSS.LN2F). The study incorporated three viability assays to comprehensively assess the impact of varying freezing rates on post-thaw cell recovery | Trypan blue | LIVE/DEAD | Fluorescence.