Biopharmaceutical Products
Many drug products require aseptic conditions along their entire production process. In this article, we will discuss essential considerations on aseptic filling in the biopharma industry.
Michael Eder
January 16, 2024
Biopharmaceutical Products
Ensuring that cell and gene therapy products are shipped at cold temperatures with robust controls is even more important for cell & gene therapies than it is for more traditional biopharmaceutical products.
Michael Mühlegger
July 8, 2024
Biopharmaceutical Products
Upstream intensification processes use high density cell banking to optimize monoclonal antibody production. How does HDCB advance cell expansion? And is seed train intensification relevant to biosimilars?
Brian Moloney
February 12, 2025
Biopharmaceutical Products
Vaccine production is characterized by ongoing changes, adaptations and improvements. In this article, we will take a look at 7 trends in global vaccine development.
Daniel Tischler
December 19, 2024
Biopharmaceutical Products
Lentiviral vectors have become important tools in gene therapy, offering new opportunities for treating a wide array of diseases. Learn more about comparison with AAVs and how lentiviral vector manufacturing challenges – from plasmid design to aseptic filling and controlled freezing – can be solved to enhance overall manufacturing efficiency.
Brian Moloney
November 5, 2024
Biopharmaceutical Products
Oligonucleotide manufacturing. Optimizing fluid management, freezing & cold storage | Purification Oligonucleotides
Michael Mühlegger
October 25, 2024
Biopharmaceutical Products
What are oligonucleotides? Nucleic acid types | RNA oligonucleotides | DNA oligos | Types of Oligonucleotides
Michael Mühlegger
October 25, 2024
Biopharmaceutical Products
Freezing cells is a process that requires more than simply placing them in a freezer with dimethyl sulfoxide (DMSO). It is a precise and meticulous process, where precision and expertise are essential. The goal is to achieve high cell viability and therefore high yield for cell-based therapies or cell banking.
Khalil Essani
October 11, 2024
Biopharmaceutical Products
Vaccine manufacturing with its fascinating process – from development to large-scale production. Learn more about Vaccine Development ✓ Vaccine Production ✓ Manufacturing processes ✓ Companies ✓ Platforms ✓ Benefits & challenges ✓ cGMP ✓ Solutions
Alexander Fuchs
September 26, 2024
Biopharmaceutical Products
This guide provides an overview of the necessary steps and considerations for preparing cells for cryopreservation. Key topics include selecting appropriate cells, cultivating and harvesting them under controlled conditions, utilizing proper cryoprotective agents, and applying specific freezing techniques.
Brian Moloney
September 3, 2024
Biopharmaceutical Products
This article explores the challenges posed by RNase contamination and the solutions that can be employed to mitigate these risks. RNase contamination | Ribonuclease inhibitors | RNase-free equipment
David Seifert
August 13, 2024
Biopharmaceutical Products
RNase contamination can lead to the degradation of RNA, thereby compromising the efficacy of RNA-based drugs. Types of RNase | RNase and DNase | Role of DEPC
David Seifert
August 12, 2024
Biopharmaceutical Products
Ensuring that cell and gene therapy products are shipped at cold temperatures with robust controls is even more important for cell & gene therapies than it is for more traditional biopharmaceutical products.
Michael Mühlegger
July 8, 2024
Biopharmaceutical Products
In biosimilar production, fluid management takes on an overarching role, as it is encountered at several manufacturing steps. This is all the more reason to deal with efficiency in fluid management – which we will do in this article.
Brian Moloney
May 14, 2024
Articles by Biopharmaceutical Products:
Articles by Manufacturing Processes:
E-Book
In this publication we show that the initial price can be deceiving and there are significant additional costs during ongoing usage in the long term. Plate freezers ensure a complete, consistent, and fast freezing (and thawing) to ensure the quality of your high-valued drug substance is maintained, and through simple lifecycle analysis they outpace conventional options regarding total costs.
E-Book
Homogeneity of pharmaceuticals plays a major role in fluid management. Liquid drugs have different viscosities, degrees of sedimentation, and other varying properties, making it difficult to standardize the aliquotation of liquids. RoSS.PADL is a homogenizing solution with kneading and cooling functions for standardizing the mixing of biopharmaceuticals precedenting the dispensation into single-use bioprocess containers. This fully automated and hence standardized process ensures homogeneous distribution of the liquids in single-use bio process containers.
E-Book
This guide for bioconjugate manufacturing with regards to fluid and cold chain management addresses challenges such as: protection against ADC toxicity, accuracy in fluid management, maintaining ADC stability after freeze-thaw cycles, transition from lab to commercialization, and cost considerations of equipment.
